Being a little philosophical, I don't think that you will not have any ties to where you have lived for a long time so moving to another locale will always come with some regrets.

Another consideration will be the aging process we will all go through, what happens when you are no longer able to climb mountains or blaze a path to the unfished waters of a cool mountain stream.

I like the idea of somewhere near the Carolina shores with easy access to saltwater fishing and monster freshwater impoundments as well as the general year long pleasant weather were leasurly rounds of golf can be had year round.